Estradiol levels are differentially suppressed by elagolix compared to leuprolide acetate
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چکیده
منابع مشابه
Therapeutic Review Leuprolide Acetate
Leuprolide acetate is a potent Gonadotropin Releasing Hormone (GnRH) agonist. The general premise behind leuprolide is that it inhibits the synthesis of lutenizing hormone and follicle stimulating hormone via a negative feedback. By reducing the production of these hormones, the drug effectively reduces estrogen and androgen production. This compound has been formulated as a depot formulation (...
متن کاملUlipristal acetate versus leuprolide acetate for uterine fibroids.
BACKGROUND The efficacy and side-effect profile of ulipristal acetate as compared with those of leuprolide acetate for the treatment of symptomatic uterine fibroids before surgery are unclear. METHODS In this double-blind noninferiority trial, we randomly assigned 307 patients with symptomatic fibroids and excessive uterine bleeding to receive 3 months of daily therapy with oral ulipristal ac...
متن کاملDelayed Oral Estradiol Combined with Leuprolide Increases Endometriosis-Related Pain
OBJECTIVES To determine if low-dose estrogen replacement can be added to GnRH agonist therapy after three months to reduce hypoestrogenic symptoms while allowing continued relief of pain in patients with endometriosis. MATERIALS AND METHODS Thirteen women with endometriosis and pain were treated with six months of leuprolide acetate in a prospective, randomized double-blind placebo controlled...
متن کاملLeuprolide acetate: a drug of diverse clinical applications.
Leuprolide acetate is a synthetic nonapeptide that is a potent gonadotropin-releasing hormone receptor (GnRHR) agonist used for diverse clinical applications, including the treatment of prostate cancer, endometriosis, uterine fibroids, central precocious puberty and in vitro fertilization techniques. As its basic mechanism of action, leuprolide acetate suppresses gonadotrope secretion of lutein...
متن کاملLow 17β-estradiol Levels Are Better Inducers of Regulatory Conditioned T Cells In-Vitro
Background: 17β-estradiol (E2) has been known to modulate immune response. Recent studies indicate that E2 at pregnancy level plays a role in regulating T cell response. Objective: To investigate the optimum dose of E2 (from 10-9 to 10-7 M) in mediating the generation of regulatory T cells (Tregs), using naïve human CD4+ T cells from healthy women. Methods: Naïve peripheral T cells were purifie...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2018
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2018.07.054